Searching…
Jan 15, 2026 · Complete information for FLG gene (Protein Coding), Filaggrin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Jan 4, 2025 · Gene target information for FLG - filaggrin (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
The FLG gene provides instructions for making a large protein called profilaggrin, which is found in cells that make up the outermost layer of skin (the epidermis). Learn about this gene and related health conditions.
丝聚蛋白（filaggrin, FLG）是人体皮肤角质层中连接角蛋白纤维的重要分子，在FLG单体协助连接下，角蛋白纤维规则地聚集，在表皮的最外层形成坚实的物理屏障，可以防止表皮水分的丢失和外界过敏物质的入侵。
Dec 24, 2024 · 本文将详细介绍FLG基因的功能、作用机制、信号通路以及与疾病的关系，帮助读者全面了解这一重要基因在皮肤健康中的作用。 FLG基因的功能 FLG基因，全名filaggrin，位于人类染色体1q21.3位置，是EF-hand domain containing, S100 fused type protein family的一员。
功能概要 该基因编码的蛋白质是一种中间丝相关蛋白，可聚集哺乳动物表皮中的角蛋白中间丝。 它最初被合成为多蛋白前体，profilaggrin (由多个 filaggrin 单元组成，每个 324 aa) ，位于透明角质颗粒中，随后被蛋白水解加工成单个功能性 filaggrin 分子。
While FLG remains the strongest genetic risk factor for AD, with up to half of the AD patients carrying a FLG mutation [2], it is to be noted that AD can develop independent of FLG mutations and not all individuals wh...
