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Jun 7, 2023 · The protein encoded by circMTHFD2L, named CM-248aa, was identified for the first time by immunoprecipitation and mass spectrometry. CM-248aa was significantly downregulated in GC, while its low expressio...
Jun 7, 2023 · CM-248aa is identified as a novel tumor suppressor and an endogenous inhibitor of the SET-PP2A interaction, which negatively regulates the PI3K-AKT, MAPK, and NF-κB pathways to inhibit GC progression.
Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions. For Research or Manufa...
Sep 30, 2024 · Non-coding RNAs (ncRNAs), including circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), are unique RNA molecules widely identified in the eukaryotic genome. Their dysregulation has been discove...
Semantic Scholar extracted view of "Circular MTHFD2L RNA-encoded CM-248aa inhibits gastric cancer progression by targeting the SET-PP2A interaction" by Haohan Liu et al.
Aug 1, 2021 · The protein encoded by circMTHFD2L, named CM-248aa, was identified for the first time by immunoprecipitation and mass spectrometry. CM-248aa was significantly downregulated in GC, while its low expressio...
The inhibitory effect of CM-248aa on the proliferation and invasion of gastric cancer cells was verified by CCK-8, invasion and migration assays in vitro. Rescue experiments confirmed that the circular RNA MTHFD2L pla...
CM-248aa was significantly downregulated in GC, while its low expression was associated with advanced tumor-node- metastasis (TNM) stage and histopathological grade. Low expression of CM-248aa could be an independent r...
May 1, 2025 · circular RNA (circRNA) is a covalently closed single-stranded RNA that lacks 5' and 3' ends and has long been considered a noncoding RNA. With the development of high-throughput sequencing and bioinforma...
Feb 26, 2024 · Research on this protein has discovered that AKT, extracellular signal-regulated kinase, and P65 all become dephosphorylated as a result of CM-248aa's binding to the acidic structural domain of the SET ...
