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Our previous study had shown that blockade of KIR2DL4 interaction in NK cells can re-sensitize breast cancer to trastuzumab treatment, which indicated that KIR2DL4 was a pivotal immune checkpoint of NK cells. Currentl...
The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2).
除非HLA-G参与，KIR2DL4促进ADCC并形成一个与IFN-y产生的调节回路，其中IFN-y通过JAK2/STAT1信号上调KIR2DL4,KIR2DL4与Fcy受体协同增加NK细胞的IFN-V分泌。
All these studies showed that KIR2DL4 plays an important role in cancer immunotherapy and targeting KIR2DL4 might be an efective approach. Due to the special structure, KIR2DL4 can deliver both activating and inhibito...
Apr 24, 2024 · AML患者中KIR2DL1、KIR2DL3、KIR2DL4表达上调与免疫浸润细胞密切相关。 此外，这项研究为骨髓免疫微环境和AML免疫治疗提供了有前景的靶点。
这篇综述深入探讨了KIR2DL4（杀伤细胞免疫球蛋白样受体2DL4）作为NK细胞关键免疫检查点的双重功能，及其与HLA-G（非经典MHC I类分子）的相互作用在肿瘤免疫逃逸中的机制。
HLA-G/KIR2DL4 信号通路的阻断提高了 HER2 阳性乳腺癌对体内曲妥珠单抗治疗的脆弱性。 这些发现为曲妥珠单抗耐药机制提供了新的见解，并证明了联合 HLA-G 和 PD-L1/PD-1 靶向治疗曲妥珠单抗耐药乳腺癌的适用性。
Elevated expression of KIR2DL4 has been observed in certain tumor types, including melanoma, lung cancer, and ovarian cancer, indicating its role in tumor evasion.
Jul 17, 2025 · Complete information for KIR2DL4 gene (Protein Coding), Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4, including: function, proteins, disorders, pathways, ortholog...
Dec 31, 2024 · 本文详细介绍了KIR2DL4基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面理解这一重要的免疫调节基因。
