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en.wikipedia.org
p53 - Wikipedia
p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers.
pmc.ncbi.nlm.nih.gov
Tumor Suppressor p53: Biology, Signaling Pathways, and...
This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with multiple diverse inpu...
www.nature.com
Targeting p53 pathways: mechanisms, structures and advances in...
Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key structural features of...
biologyinsights.com
What Is the P53 Gene and How Does It Prevent Cancer?
The p53 gene, officially known as TP53, is a critical tumor suppressor in human biology. This gene encodes the p53 protein, which acts as the cell’s primary safeguard against the uncontrolled proliferation that charac...
www.cell.com
Understanding the complexity of p53 in a new era of tumor...
May 9, 2024 · Here, we review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that contribute to tumor suppression.
medlineplus.gov
TP53 gene: MedlinePlus Genetics
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividi...
www.sciencedirect.com
P53 - an overview | ScienceDirect Topics
p53p53 is a tumor suppressor gene and is commonly mutated in several human cancers. In routine diagnostic surgical pathology, mutation status is assessed based on p53 expression by IHC.
www.masseycancercenter.org
Researchers identify Achilles’ heel in lung cancer through common...
Mar 9, 2026 · Mutations in p53 are very common in all cancers, but they are observed at an even higher rate in lung cancer, appearing in up to 70-90% of tumors for certain forms of disease. A normal p53 gene is a tumo...
www.bioinformatics.org
Primary information of p53 gene
p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression. It is very important for cells in multicellular orga...
medicalxpress.com
Common p53 genetic mutation reveals Achilles' heel in lung cancer
Mar 10, 2026 · A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors ...