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www.genecards.org
ABCC1 Gene - GeneCards | MRP1 Protein | MRP1 Antibody
Jan 14, 2026 · Complete information for ABCC1 gene (Protein Coding), ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group), including: function, proteins, disorders, pathways, orthologs, and expression.
en.wikipedia.org
ABCC1 - Wikipedia
ABCC1 plays a role in the multidrug resistance of cancerous tumor cells due to its ability to transport many chemotherapeutic drugs out of the cells. The ABCC1 transporter protein is especially prevalent in neuroblast...
zhuanlan.zhihu.com
Cell Chem Biol重大发现！ABCC1竟成癌细胞抵抗PROTAC治疗的关键“屏障”
Dec 24, 2024 · ABCC1被明确认定为癌细胞中主要的PROTAC耐药因子。 在针对 MZ1 及相关PROTACs的筛选实验中，ABCC1基因对应的单导向RNA（sgRNAs）出现了显著缺失的情况。 而过表达ABCC1的cDNA后，癌细胞对MZ1的耐药性显著增强，这一结果有力地证明了ABCC1在PROTAC外排过程中发挥着关键作用。
www.medchemexpress.cn
ATP 结合盒亚家族 C 成员 1（ABCC1）基因 | MCE
ATP 结合盒亚家族 C 成员 1： 由该基因编码的蛋白质是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White) 。
www.nature.com
Substrate recognition diversity and transport dynamics of ABCC1
Nov 25, 2025 · Here, we present ten cryo-EM structures of ABCC1 in different functional states, providing systematic insights into its substrate recognition diversity and transport dynamics.
www.bafang.org.cn
ABCC1基因的功能与作用机制解析 - 八方基因
Dec 19, 2024 · ABCC1基因的功能 ABCC1，全称为ATP binding cassette subfamily C member 1，是ATP结合盒（ABC）转运蛋白家族的一员。 这个家族的成员以其能够利用ATP水解产生的能量来转运各种物质跨膜而闻名。 ABCC1 主要在肝脏、肠道、肾脏和胎盘中表达，扮演着重要的物质转运角色。
pmc.ncbi.nlm.nih.gov
Human ABCC1 Interacts and Colocalizes with ATP Synthase
Human ABCC1 is a member of the ATP-binding cassette (ABC) transporter superfamily, and its overexpression has been shown to cause multidrug resistance by active efflux of a wide variety of anticancer drugs. ABCC1 has ...