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Jul 17, 2025 · Complete information for CBFB gene (Protein Coding), Core-Binding Factor Subunit Beta, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. [5][6] The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to t...
Feb 18, 2021 · In conclusion, by identifying the RUNX–CBFβ-driven enhancer that regulates Irf8 expression from the earliest stage, we uncovered the epigenetic regulatory mechanisms by which a single TF, IRF8 ...
CBFβ-MYH11阳性AML患者受体酪氨酸激酶基因家族基因突变发生率较高，如FLT3、KRAS、KIT等，可能是促进AML发生和发展的协同因素 [10]，检测基因异常将有助于预测治疗结果 [13]。
核心结合因子β亚基： 由该基因编码的蛋白质是属于 PEBP2/CBF 转录因子家族的异二聚体核心结合转录因子的 β 亚基，该转录因子主要调节一系列造血功能 (例如 RUNX1) 和成骨 (例如 RUNX2) 特异性基因. beta 亚基是一个非 DNA 结合的调节亚基；它通过变构增强 α 亚基的 DNA 结合，因为复合物结合到各种增强 ...
The CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). Learn about this gene and related health conditions.
Jan 5, 2025 · CBFB基因概述 CBFB基因，全名为core-binding factor subunit beta，位于染色体16q22.1上。这个基因编码的蛋白质是PEBP2B，在细胞核内发挥重要作用，参与调控基因的转录过程。CBFB蛋白通常与另一个蛋白质RUNX1形成复合物，共同调控造血干细胞的分化。
在白血病染色体异常中，CBFα2（AML1）和CBFβ受到累及，累及CBF的融合基因在功能上多通过表现为CBF的负显性作用导致白血病的发生。
我们最近表明 RUNX1 在小鼠模型中对于 Cbfb-MYH11 诱导的白血病发生是必不可少的。 我们发现 RUNX1 与 CBFB-MYH11 编码的融合蛋白 CBFβ-SMMHC 相互作用，直接调节白血病发生的关键基因（Zhen 等人，Blood，2020）。
Mice lacking chondrocyte- specific Cbfβ had a shortened appendicular skeleton and delayed endochondral bone formation, as well as downregulation of the chondrocyte- regulating gene.85 Cbfβ is crucial for chondrocyte d...
