Searching…
CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol (GPI) tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directl...
The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages and monocytes.
Jul 17, 2025 · Complete information for CD14 gene (Protein Coding), CD14 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Dec 1, 2023 · Abstract CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage-associated molecular p...
Consistent with these broader functions, CD14 expression is altered in a variety of non-immune cell types in response to a several of disease states. More-over, soluble CD14 activated by factors from both pathogens an...
Sep 24, 2024 · Magri et al. demonstrate that TLR adaptor CD14 can mediate this switch between death and inflammation in myeloid cells by internalizing the Fas receptor to a pro-death complex and preventing inflammation.
CD14 is a protein marker found on the surface of monocytes, crucial for recognizing microbial pathogens and initiating the body’s immune response. Essentially, it acts as a cellular control tower, coordinating immune ...
In this review, we summarize advancements in the basic biology of the CD14 including its structure, binding ligands, signaling pathways, and its roles in the pathogenesis of inflammation, atherosclerosis, tumor and me...
Learn about the CD14 gene, its function, expression, and role in various health conditions. Explore its involvement in inflammation, immunity, and disease susceptibility.
Aug 1, 2019 · The terminal effects of CD14 in inflammation may depend on many factors including the site of inflammation, the essence of diseases, the level of CD14 expression, the characteristics of CD14 ligands and ...
