c-erbB-2基因检测 (c-erbB-2,neu,HER-2) - 百度百科
c-erbB-2基因检测 (c-erbB-2,neu,HER-2)是针对原癌基因c-erbB-2的医学检测项目,该基因编码的P185蛋白在乳腺癌等多种肿瘤中存在过度表达和扩增,其阳性表达可作为乳腺癌预后的独立评估指标。 检测过程需严格避免标本污染,正常结果为不表达或低表达。
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c-erbB-2基因检测 (c-erbB-2,neu,HER-2)是针对原癌基因c-erbB-2的医学检测项目,该基因编码的P185蛋白在乳腺癌等多种肿瘤中存在过度表达和扩增,其阳性表达可作为乳腺癌预后的独立评估指标。 检测过程需严格避免标本污染,正常结果为不表达或低表达。
A protein involved in normal cell growth. C-erbB-2 may be made in larger than normal amounts by some types of cancer cells, including breast, ovarian, bladder, pancreatic, stomach, and esophageal cancers.
HER2 / neu is the human epidermal growth factor receptor 2; HER2 gene encodes a transmembrane growth factor receptor that regulates cell growth and survival
Apr 29, 2025 · HER2 基因突变会导致该基因编码的蛋白质异常激活,进而促进肿瘤细胞的增殖、转移和侵袭,同时增加肿瘤对传统化疗药物的耐药性。 因此,对 HER2 的检测和治疗成为了多种肿瘤治疗的关键方向。 目前,已经成功开发出一些针对 ErbB2 靶向治疗的药物。
HER-2/neu (also known as c-erbB-2) oncogene is a member of the epidermal growth factor receptor family and its amplification is one of the most common genetic alterations associated with human breast cancer. Preclinic...
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated fro...
Oncogene products serve as growth factors, growth factor receptors, and cytosolic and nuclear regulatory proteins. Increased levels of oncogene products, such as ras, myc, c- erb -B2, and bcl -2, have been associated ...
Jan 23, 2020 · HER-2 的学名叫“c-erbB-2癌基因”,20%~30% 的浸润性乳腺癌患者具有 HER-2 基因扩增,在细胞表面该基因表达产物—c-erbB-2 蛋白水平过度表达提示肿瘤细胞增殖活跃,容易复发和转移。
C-erbB-2是一种癌基因。 此基因所编码的蛋白是相对分子质量为185 000的穿膜蛋白,可以抑制酪氨酸激酶活性。 该基因的过度表达和扩增可见于多种肿瘤,尤其是腺癌中,与肿瘤的分化程度和分级有密切关系。
Expression of ERBB2 (c-ERB-2, c-ERB2, CD340, HER-2, HER2, MLN-19, NEU, NGL, p185 (erbB2)) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.