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Mar 25, 2025 · This Review discusses the mechanisms of coat assembly and disassembly, and cargo recognition by COPII carriers.
Oct 1, 2011 · This review describes the COPII and COPI coating machineries that generate carrier vesicles and the tethers and SNAREs that mediate COPII and COPI vesicle fusion at the ER-Golgi interface.
网格蛋白包覆的囊泡有几种类型，每种都专门用于不同的运输步骤，COPI 和 COPII 包覆的囊泡可能也有类似的多样性。 例如，网格蛋白包覆的囊泡介导从高尔基体和质膜的转运（上图绿色），而COPI （红色）和COPII （蓝色）包覆的囊泡常介导ER和高尔基间的转运。
COPⅡ被膜小泡是由外被蛋白Ⅱ（COPⅡ）复合体包裹形成的运输小泡，主要介导内质网（ER）至顺面高尔基体的非选择性物质运输，并参与从顺面高尔基体到高尔基体中间膜囊、从中间膜囊到反面高尔基体的运输。
COPII is an important component of the protein secretory pathway in eukaryotes and plays an essential role in maintaining the homeostasis of various intracellular organelles.
Apr 1, 2021 · Here we visualise the complete, membrane-assembled COPII coat by cryo-electron tomography and subtomogram averaging, revealing the full network of interactions within and between coat layers.
COPII 是一种多亚基蛋白复合物，主要由 Sec23-Sec24 和 Sec13-Sec31 等亚基组成。 Sec23-Sec24 亚复合物在货物识别和募集方面发挥着关键作用，而 Sec13-Sec31 亚复合物则参与运输载体的组装和塑形。 这些亚基相互协作，共同完成从内质网到高尔基体的囊泡运输过程。
Dec 22, 2011 · The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved thr...
Long known as a coat system that generates small transport vesicles from the endoplasmic reticulum (ER), the COPII coat also drives ER export of cargo proteins that are too large to be contained within these canonical...
Jan 1, 2011 · Then, we examine more recent discoveries that show how deficiencies in COPII can lead to disease. Finally, we briefly explore how additional factors can work with the COPII proteins to enhance transport ...
