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Jan 15, 2026 · Complete information for RIGI gene (Protein Coding), RNA Sensor RIG-I, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
These results expand the genotypic spectrum of DDX58-associated disease, provide the first detailed description of ocular and dermatological phenotypes, expand our understanding of the molecular pathogenesis of this c...
RIG-I is encoded by the DDX58 gene in humans. [9][15] RIG-I is a helical ATP-dependent DExD/H box RNA helicase with a repressor domain (RD) on the C-terminus that binds to the target RNA. [5][9] Included on the N-term...
有基于此，刘志红院士团队从特殊类型LN患者入手，对1376例患者进行了全外显子测序研究，发现有5个特殊类型LN家系中存在共同的基因突变--DDX58 R109C，且进一步 生物信息学 分析证实其可能是新的LN致病突变。
Conclusion DDX58 is a key immune-related gene in ischemic HF and may play a crucial role in the relationship between ischemic HF and cancer. Pan-cancer analysis suggests that DDX58 is a promising clinical prognostic m...
维甲酸诱导基因-I[5] （RIG-I，retinoic acid-inducible gene I）化学式为：C 4778 H 7527 O 1409 N 1257 S 46[6]，是 脊椎動物 細胞質 中的一種 模式识别受体 （PRR），結構上屬於 DExD/H-box 类 RNA解旋酶 [7][8][9]，在人類 基因組 中由 DDX58 基因編碼 [10]，其 N端 有兩個 CARD結構域， C端 則可與 RNA 結合，為...
DDX58的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为DEAD盒蛋白，其特征为保守基序天冬氨酸 - 谷氨酸 - 丙氨酸 - 天冬氨酸（DEAD），是它们在许多涉及RNA结合和RNA二级结构的改变的细胞过程的牵连推定的RNA解旋酶。该基因编码含有RNA解旋死box蛋白图案和caspase募集域（CARD ...
Nov 19, 2022 · RIG-I/DDX58 plays a key role in host innate immunity. However, its therapeutic potential for inflammation-related cancers remains to be explored. Here we identify frameshift germline mutations of ...
Discover the critical role of the DDX58 gene (RIG-I) in antiviral immunity. Learn about its function as a pattern recognition receptor, its involvement in interferon production, and its significance in human health.
DDX58 Protein Function Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses inclu...
