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Oct 20, 2023 · In this complex scenario of atherosclerosis, macrophages participate in the whole process, including the initiation, growth and eventually rupture and wound healing stages of artery plaque...
May 2, 2023 · We investigated whether NETosis is a cell-intrinsic effect in neutrophils or is mediated indirectly by cellular crosstalk from macrophages to neutrophils involving IL-1β.
Mar 6, 2026 · In AS, NETs and macrophages establish a self-sustaining vicious cycle—initiated by lipid infiltration, perpetuated through foam cell formation and inflammatory amplification, and exacerbated by impaired ...
Oct 1, 2025 · Adverse clinical outcomes are usually a result of plaque erosion or rupture which result in acute luminal thrombosis with ensuing tissue ischaemia. Immune cell infiltration and the associated inflammatio...
Sep 6, 2025 · Neutrophil extracellular traps (NETs) act as a double-edged sword: while essential in infection control and wound healing, excessive NETosis drives chronic inflammation and tissue damage. Mounting eviden...
Jan 20, 2024 · The development and rupture of atherosclerotic plaques is a major contributor to myocardial infarctions and ischemic strokes. The dynamic evolution of the plaque is largely attributed to monocyte/macrop...
Mar 19, 2020 · The NET-macrophage interaction is a likely contributing factor to persistent macrophage inflammation in the plaques of diabetic mice, even after lipid lowering.
The authors speculate that these NETs may contribute to plaquerupture and subsequent thrombus formation. In accordance with these findings, platelet-derived high-mobility group box 1 protein can facilitate NET formati...
Nov 19, 2021 · In the present study, we aimed to investigate the effect of NETs on human and murine macrophages in respect to the expression of pro-inflammatory cytokines, matrix metalloproteinases (MMPs) and uptake o...
May 23, 2025 · At advanced phases of atherosclerosis, the rupture and thrombogenesis of vulnerable plaques emerge as primary triggers for acute cardiovascular events and fatalities.
