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Glypican 3 (GPC3) is a membrane-anchored heparan sulfate proteoglycan that regulates Wnt/β-catenin and Yap pathways. It is encoded by a gene on the X chromosome and has multiple isoforms and functions in various tissu...
Abstract Glypican3 (GPC3), initially cloned from rats 40 years ago, deeply participates in the development and homeostasis of multiple tissues and organs. Dysregulation of GPC3 is associated with cancerous and noncanc...
Jan 15, 2026 · GPC3 is a protein coding gene that encodes a cell surface heparan sulfate proteoglycan that regulates various signaling pathways and cellular processes. It is involved in diseases such as Simpson-Golabi...
The GPC3 gene provides instructions for making a protein called glypican 3. Learn about this gene and related health conditions.
Nov 1, 2025 · Glypican-3 (GPC3) is a membrane-anchored heparan sulfate proteoglycan overexpressed in many hepatocellular carcinomas (HCCs) while minimally present in normal adult liver, making it an attractive target ...
Mar 23, 2026 · A Study of Metabolically Armed GPC3 CAR-T Cells Injection (Meta10-GPC3) in Patients with Unresectable Recurrent/Metastatic Hepatocellular Carcinoma.
Nov 27, 2024 · We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion ...
