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Jul 19, 2024 · Recombinant human type 5 adenovirus (H101) is an oncolytic virus used to treat nasopharyngeal carcinoma.
This study demonstrates the potential efficacy of combining H101 with nivolumab in treating refractory advanced HCC, with well-tolerated toxicities.
May 29, 2024 · Recombinant Human Adenovirus Type 5 (H101), the world’s first oncolytic virus antitumor drug in China, can induce cell death, expose tumor antigens, provide adjuvants for anti-tumor immune priming, and ...
Our results demonstrated that H101 infection induced downregulation of CD47 in infected cancer cells, which promoted macrophages to phagocytose cancer cells. In vivo, the combined therapy of H101 with Camrelizumab dem...
Sep 19, 2025 · Recombinant human adenovirus type 5 (H101) was demonstrated to enhance the efficacy of transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC). This study aims to analyze the effica...
Feb 7, 2024 · H101 injections show promise in reversing immune checkpoint inhibitor resistance, extending OS in PR cases.
Background: The aim of this study was to analyze the effectiveness and safety of H101 in Chinese patients with malignant pleural effusion and ascites (MPE/MA) in the real world.
May 29, 2024 · The efficacy of recombinant human adenovirus type 5 (H101) intra-tumor therapy in persistent/recurrent/metastatic gynecological cancer and the exploration of changes in tumor microenvironment.
H101 is a recombinant human type-5 adenovirus (Ad5), in which E1B-55 kDs gene has been totally deleted. The H101 virus produced by Shanghai Sunway Biotech, also contains a deletion of 78.3-85.8 μm gene segment in the ...
This retrospective cohort study aimed to evaluate the clinical outcomes of H101 combined with chemotherapy for advanced gastric carcinoma (GC) patients. The advanced GC patients, who were treated with H101 and/or chem...