Searching…
Oct 11, 2023 · The H3K27Mmutation is associated with distinct tumor molecular biology and clinical outcomes. The H3K27Mmutation results in an altered 3D chromatin structure and transcription regulation. H3K27Mmutant g...
The median overall survival of H3K27M-mutant gliomas and the 70 H3K27M wild-type gliomas were both 17 months. For young patients (age ≤ 35), The median survival time of the H3K27M-mutant was 18 months, while that of t...
H3K27M是弥漫性中线胶质瘤内常见的组蛋白突变，与预后不良相关。 美国密歇根大学医学院的Carl Koschmann等综述临床前研究的最新数据和靶向H3K27M的临床试验结果，并阐述连续体液活检诊断和监测治疗DMG的进展，相关结果发表在2020年2月的《Current Oncology Reports》在线。
H3K27M gliomas and PFA-EP were associated with distinct OPC, oligodendrocyte, astrocyte, and ependymal programs (Figure 1c). Thus, cell identity is a dominant source of intra-tumoral transcriptional variation in these tumors.
Dec 5, 2022 · Comprehensive genomic profiling of human H3K27Mmutant diffuse midline gliomas, combining single-cell RNA sequencing and ATAC sequencing with bulk ChIP sequencing and other data, proposes...
Sep 1, 2024 · At our institution, we always attempt interrogation for the presence of an H3K27Mmutation via tissue diagnosis (surgery, if possible) in patients with midline tumors with MRI characteristics of HGGs, reg...
四川大学华西医院病理科团队回顾性分析了164例诊断为H3K27M突变的弥漫中线胶质瘤患者的临床和分子特征。 结果表明，94例为成人（＞18岁），70例为儿童（≤18岁），152例（92.7%）患者检出H3.3K27M突变，12例（7.3%）检出H3.1K27M突变。
