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Nov 13, 2025 · GeneCards Summary for HNF1A Gene HNF1A (HNF1 Homeobox A) is a Protein Coding gene. Diseases associated with HNF1A include Maturity-Onset Diabetes Of The Young, Type 3 and Type 1 Diabetes Mellitus 20. Am...
Mutations in the HNF1A gene have been known to cause diabetes. [10] The HNF1A gene also contains a SNP associated with increased risk of coronary artery disease.
Jun 22, 2024 · HNF4A and HNF1A encode transcription factors that are important for the development and function of the pancreas and liver.
Here, we review the current understanding of HNF1A in multiple organs, including the pancreas, and discuss how HNF1A mutations contribute to the pathogenesis of diabetes, primarily focusing on beta cell dysfunction.
The HNF1A gene provides instructions for making a protein called hepatocyte nuclear factor-1 alpha (HNF-1α). The HNF-1α protein acts as a transcription factor, which means it attaches (binds) to specific regions of DN...
本文重点介绍HNF1α基因多态性、HNF1A-MODY3、HNF1A相关的T2D和GDM，以及相关的发病机制和治疗方法。 希望本综述通过总结HNF1α突变引起的血糖异常的临床异质性，为HNF1α异常引起的糖尿病的精准个体化治疗提供有价值的参考。
HNF1A基因编码的蛋白质是一种转录因子，对肝脏特异性基因表达至关重要。 该基因突变可导致青年晚期糖尿病3型（MODY3）及肝脏腺瘤。
HNF1同源蛋白BOOX A （肝细胞核因子1同源物A），也称为HNF1A ，是染色体12上的人类基因。 它在许多组织和细胞类型中无处不在。
Jan 1, 2024 · HNF1A and HNF4A, together with FOXA2 and forkhead box protein A3 (FOXA3), create a regulatory network responsible for the transcriptional program of the β cells of langerhans islets and hepatocytes.
HNF1A的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的蛋白质是用于几种肝特异性基因的表达所需的转录因子。
