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The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.
Jul 24, 2025 · The Interleukin-2 Receptor (IL-2R) is a complex protein on the surface of certain immune cells, orchestrating the body’s defenses. It acts as a receiver for the cytokine Interleukin-2 (IL-2), a signalin...
A key breakthrough in understanding how the IL-2 receptor functions came from the discovery that the IL-2 receptor uses Janus family kinase (JAK) members to induce signal transduction (67 – 70).
Sep 1, 2020 · The interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain...
Mar 12, 2024 · Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotox...
IL-2 signals through a IL-2 receptor, a complex consisting of three chains, termed alpha (CD25), beta (CD122) and gamma (CD132). The gamma chain is common to all family members.
Jan 8, 2025 · The soluble interleukin-2 receptor (sIL-2R) is a novel biomarker associated with a variety of immune-mediated diseases.
IL-2 receptor (IL-2R) is considered as a heterotrimeric protein that represents three subunits or chains: α (CD25), β (CD122) and γ (CD132). The different and separate expressions of these receptor chains on various i...
Aug 8, 2018 · The other two IL-2 receptor chains, IL-2Rβ and IL-2Rγ, are constitutively expressed on immune cells including resting T cells, CD8 + T cells, NK cells and certain other cell types.
For IL-2 to perform its functions, it must interact with the Interleukin-2 Receptor (IL-2R) on the surface of immune cells. This interaction influences overall immune system activity.
