Searching…
Jan 15, 2026 · Complete information for KEAP1gene (Protein Coding), Kelch Like ECH Associated Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression.
Dec 31, 2024 · KEAP1基因的突变与多种疾病的发生密切相关，特别是在癌症和神经退行性疾病中。 例如，某些类型的肺癌和卵巢癌中，KEAP1基因的突变会导致Nrf2的持续激活，从而引发一系列病理变化。 此外，KEAP1的突变还可能与阿尔茨海默病等神经退行性疾病有关。
而在氧化应激或有毒物质存在时，KEAP1的构象发生变化，失去对NRF2的抑制作用，使NRF2稳定并转位入核，激活包括抗氧化酶、解毒酶在内的多种保护性基因的转录。 该通路在癌症、神经退行性疾病和炎症等多种疾病中具有重要作用。
Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of ...
Oct 26, 2023 · Our study provides new insight into the role of KEAP1 mutations in immune evasion, paving the way for novel immune-based therapeutic strategies for KEAP1- mutant cancers.
Jun 20, 2022 · KEAP1 functions as (i) a substrate adaptor for a Cullin 3 (CUL3)-based E3 ubiquitin ligase that targets NRF2 for ubiquitination and proteasomal degradation, and (ii) a cysteine-based sensor for a myriad...
在正常状态下，KEAP1将NRF2锚定在细胞质中并促使其降解；当细胞受到氧化压力时，KEAP1释放NRF2，使其进入细胞核激活抗氧化基因表达，维持细胞稳态。 该蛋白的功能异常与癌症、神经退行性疾病等多种疾病密切相关。
