zhuanlan.zhihu.com
IF14.3! 中科院1区！Mfn2/Hsc70介导的线粒体-脂滴相互作用在心肌脂肪酸氧化代谢和能量供给中的关键作用 -...
线粒体融合蛋白Mfn2 是一种在线粒体外膜上的蛋白质，它在细胞中扮演着调节线粒体形态和功能的重要作用。 最近的研究发现，Mfn2在心脏脂质代谢中可能发挥着关键作用，尤其是在脂质超载的条件下。
mfn2蛋白
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en.wikipedia.org
MFN2 - Wikipedia
It has been also described that Mfn1 and Mfn2 are ubiquitously expressed yet they display different relative levels of expression between tissues, with MFN2 being the predominantly expressed mitofusin in the brain and...
www.genecards.org
MFN2 Gene - GeneCards | MFN2 Protein | MFN2 Antibody
Jul 17, 2025 · MFN2 is a gene that encodes a mitochondrial membrane protein involved in mitochondrial fusion and metabolism. Mutations in MFN2 cause neuropathy and stroke, and the gene has two transcript variants and ...
pmc.ncbi.nlm.nih.gov
Structure, function, and regulation of mitofusin‐2 in health ...
In this review, we summarize the current knowledge of the structural and functional properties of Mfn2 as well as its regulation in different tissues, and also discuss the consequences of aberrant Mfn2 expression.
www.nature.com
Mitofusin 2: from functions to disease | Cell Death & Disease
Feb 28, 2018 · Facts MFN2, an outer mitochondrial membrane GTPase, is critical for mitochondrial fusion, which in turn affects mitochondrial dynamics, distribution, quality control, and function.
jcpu.cpu.edu.cn
线粒体融合蛋白2:潜在的药物靶点
粒体的形态和功能存在密切关联。线粒体融合蛋白2(MFN2) 是一种跨膜蛋白,主要存在于内质网和线粒体外膜上, 其能够促进线粒体的融合,保证细胞内线粒体网络 的完整性,从而维持线粒体功能[1]
health.baidu.com
mfn2蛋白 | 百度健康·医学科普
MFN2蛋白 （Mitofusin 2）是一种位于线粒体外膜的 GTP酶，主要参与调控 线粒体融合 和 动态平衡，在能量代谢、细胞存活及疾病发生中起关键作用。它与线粒体形态、功能调控及细胞器间互作紧密相关，异常表达可导致神经退行性疾病、代谢紊乱等多种病理状态。
ccj.pku.edu.cn
线粒体融合蛋白2的结构与功能研究进展 - pku.edu.cn
线粒体融合蛋白2 (mitofusin 2,Mfn2)位于线粒体外膜上,是线粒体外膜融合的重要蛋白之一。 研究发现,它不仅参与调控线粒体形态结构,还与细胞代谢、增殖、凋亡密切相关。
www.sciencedirect.com
MFN2 - an overview | ScienceDirect Topics
Although the numerous functions of MFN2 in cancer need more investigation, it is clear that MFN2 is directly engaged in several important physiological mechanisms in cancerous cells, including cell apoptosis, cell pro...
www.ebiotrade.com
突破认知：MFN2 在蛋白质稳态监测中的非融合新角色 - 生物通
Feb 11, 2025 · 他们将目光聚焦在一种名为 Mitofusin 2（MFN2）的蛋白上，试图探究它在线粒体和细胞蛋白质稳态调控中的具体作用。 经过一系列严谨的实验，研究人员发现，MFN2 在蛋白质质量控制方面有着意想不到的重要作用，而且这个作用独立于它在线粒体形态重塑中的功能。