rag2基因

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Rag2-KO基因敲除小鼠——免疫缺陷C57小鼠模型 - 知乎

Rag2基因敲除小鼠因无法完成淋巴细胞成熟过程,导致严重联合免疫缺陷(SCID),表现为T细胞和B细胞缺失,但NK细胞功能正常。 该模型是研究免疫缺陷、肿瘤移植和自身免疫性疾病的核心工具。 二、构建方式 CRISPR/Cas9 技术: 直接敲除Exon3部分序列,导致移码 ...

www.genecards.org

RAG2 Gene - GeneCards | RAG2 Protein | RAG2 Antibody

Jan 15, 2026 · Complete information for RAG2 gene (Protein Coding), Recombination Activating 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

medlineplus.gov

RAG2 gene: MedlinePlus Genetics

The RAG2 gene provides instructions for making a member of a group of proteins called the RAG complex. Learn about this gene and related health conditions.

www.bafang.org.cn

RAG2基因在细胞中的表达调控机制 - 八方基因

Jan 2, 2025 · RAG2基因的功能 RAG2基因的主要功能是参与V (D)J重组过程,这是免疫系统中产生多样性抗体和T细胞受体的重要步骤。 简单来说,RAG2蛋白与另一个蛋白RAG1协作,切割DNA,使得免疫细胞能够重排其基因,生成各种不同的抗体和T细胞受体。

www.modelorg.com

Rag2| Rag2-KO免疫缺陷小鼠|南模生物

作为Rag2基因敲除小鼠,皮下接种肝癌组织块和肿瘤细胞后能形成肿瘤,并且可以增长。 由FACS检测小鼠外周静脉血中的T、B淋巴细胞生成量极低,与Nude小鼠T、B淋巴细胞产生量相当甚至更低,与野生型小鼠相比具有显著性差异;而NK细胞含量并未降低。

www.nature.com

CRISPR-Cas9 engineering of the RAG2 locus via ... - Nature

Oct 27, 2023 · RAG2-SCID is a primary immunodeficiency caused by mutations in Recombination-activating gene 2 (RAG2). Here the authors report a RAG2 correction strategy that replaces the entire endogenous coding ...

www.ncbi.nlm.nih.gov

RAG2 recombination activating 2 - NIH Genetic Testing ...

RAG2 recombination activating 2 Gene ID: 5897, updated on 27-Aug-2024 Gene type: protein coding Also known as: RAG-2 See all available tests in GTR for this gene Go to complete Gene record for RAG2 Go to Variation Vie...