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Jan 15, 2026 · Complete information for RASA1 gene (Protein Coding), RAS P21 Protein Activator 1, including: function, proteins, disorders, pathways, orthologs, and expression.
Jan 8, 2025 · RASA1基因概述 RASA1，也被称为 p120GAP 或 p120RASGAP，是一个位于5号染色体长臂14.3区域的基因。 它的主要功能是作为 RAS蛋白的负调控因子，通过调节RAS信号通路来影响细胞的生长、分化和存活。
RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120- kDa cytosolic human protein that provides two principal activities:
The RASA1 gene provides instructions for making a protein called p120-RasGAP. This protein helps regulate the RAS/MAPK signaling pathway, which transmits signals from outside the cell to the cell's nucleus.
Capillary malformation-arteriovenous malformation syndrome (CM-AVM) is an autosomal dominant disorder caused by RASA1 mutations. Multifocal, small, round-to-oval, pinkish-to-red cutaneous capillary malformations are s...
Mar 3, 2016 · Heterozygous inactivating RASA1 mutations were detected in 6 families manifesting atypical capillary malformations associated with arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.
RAS p21 蛋白激活因子 1： 该基因编码的蛋白质位于细胞质中，是 GTP 酶激活蛋白 GAP1 家族的一部分。 该基因产物刺激正常 Ras p21 的 GTPase 活性，但不刺激其致癌对应物。
This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/E...
这个基因编码的蛋白质位于细胞质中，是GTP酶激活蛋白GAP1家族的成员。 该基因产物刺激正常RAS p21的GTP酶活性，但不刺激其癌基因对应物。 作为RAS功能的抑制物，该蛋白质增强RAS蛋白的弱内在GTP酶活性，导致RAS的失活GDP结合形式，从而控制细胞增殖和分化。
Protein Ras GTPase-activating protein 1 Gene RASA1 Status UniProtKB reviewed (Swiss-Prot) Organism
