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Jan 15, 2026 · Complete information for SGK1 gene (Protein Coding), Serum/Glucocorticoid Regulated Kinase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene. SGK1 belongs to a subfamily of serine/threonine kinases that is u...
Jan 9, 2025 · SGK1基因的基本信息 SGK1，全称 serum/glucocorticoid regulated kinase 1，位于人类染色体6q23.2上。这是一个编码蛋白质的基因，其产物在细胞信号传导中起到关键作用。SGK1基因的OMIM编号为602958，Ensembl编号为ENSG00000118515，UniProt编号为O00141。
SGK1 可以磷酸化转录因子 FOXO3a，导致其被滞留在细胞质中，无法进入细胞核启动促凋亡基因（如 BIM）的转录，从而促进细胞存活。 这与 AKT 的机制几乎一致。 临床景观：高血压与肿瘤耐药 SGK1 的功能异常直接关联心血管代谢疾病和恶性肿瘤的难治性。
Abstract Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase belonging to the protein kinase A, G, and C (AGC) family. Upon initiation of the phosphoinositide 3-kinase (PI3K) signaling path...
血清/糖皮质激素调节激酶 1： 该基因编码在细胞应激反应中起重要作用的丝氨酸/苏氨酸蛋白激酶。 这种激酶激活某些钾、钠和氯通道，表明参与细胞存活、神经元兴奋性和肾钠排泄等过程的调节。 这种酶被蛋白质磷酸化激活，并通过泛素化和蛋白酶体途径降解。
Feb 1, 2024 · Due to its significant role in the pathogenesis of numerous diseases, SGK1 can be exploited as a potential therapeutic target to address challenging health problems. SGK1 is associated with the developme...
Mar 31, 2021 · 非癌细胞通常在脱离细胞外基质后死亡，但SGK1活性可促进脱离后的存活，因此增加了癌症扩散或转移的机会。 整联蛋白介导的对细胞外基质（ECM）蛋白的附着丧失会触发各种影响细胞生存力的细胞变化。
May 3, 2025 · Gene target information for SGK1 - serum/glucocorticoid regulated kinase 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
