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Jan 15, 2026 · SIAH1 (Siah E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with SIAH1 include Buratti-Harel Syndrome and Complex Neurodevelopmental Disorder.
siah E3 泛素蛋白连接酶 1： 该基因编码的蛋白质是七缺席同源物 (SIAH) 家族的成员。该蛋白质是一种 E3 连接酶，参与泛素化和蛋白酶体介导的特定蛋白质降解。这种泛素连接酶的活性与某些形式的帕金森病的发展、细胞对缺氧反应的调节和细胞凋亡的诱导有关。选择性剪接会产生几种额外的转录本 ...
This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome -mediated degradation of spec...
Jan 7, 2025 · 作用机制 SIAH1通过识别特定的底物蛋白，并将泛素分子共价连接到这些蛋白上，从而启动它们的降解过程。这一过程对于维持细胞内环境的稳定性和调控细胞功能至关重要。例如，SIAH1可以调控肿瘤抑制蛋白p53的稳定性，通过影响p53的降解来调节细胞的生存和死亡。
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Siah1 is the E3 ubiquitin ligase for ELL2 polyubiquitination and proteasomal degradation. In sharp contrast to SIAH1/SIAH2 and UBCH8, TRIAD1 binding to PML-RARalpha has no effect on its turnover. Taken together, our d...
E3 ubiquitin-protein ligase SIAH1 is a protein in humans that is encoded by SIAH1 gene. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ...
