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Jul 17, 2025 · TAB2 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2) is a Protein Coding gene. Diseases associated with TAB2 include Congenital Heart Defects, Multiple Types, 2 and Cardiac Anomalies-Short Stat...
Transforming growth factor β-activated protein kinase 1 (TAK1)-binding protein 2 (TAB2) and its close homolog TAB3 are initially characterized as adapter proteins essential for TAK1 activation in response to interleuk...
Aug 27, 2004 · In this report, we show that TAB2 and TAB3 bind to K63-linked polyUb chains through a highly conserved C-terminal zinc finger (ZnF) domain. Mutations of this ZnF domain abolished the ability of TAB2 and...
Sequence analysis predicted that the TAB2 protein contains 693 amino acids and has a molecular mass of 77 kD. One distinctive feature of the TAB2 protein is the presence of amino acids (residues 535 to 609) that have ...
TGF-β 活化激酶 1 (MAP3K7) 结合蛋白 2： 该基因编码的蛋白质是 MAP3K7/TAK1 的激活剂，它是 IL-1 诱导的核因子 kappaB 和 MAPK8/JNK 激活所必需的。 该蛋白与 TRAF6、MAP3K7 和 TAB1 形成激酶复合物，因此它充当连接 MAP3K7 和 TRAF6 的衔接子。
Tab2 has a role in the inflammatory signal transduction pathway and is involved in the reversal of NCoR-dependent and NFkB- or APP-mediated gene repression and androgen antagonist response.
Sep 1, 2025 · This study investigates the role of TAB2, an adaptor protein traditionally linked to TAK1 activation in the TNF pathway.
Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negative mutant TA...
其中TAB2 和TAB3 是同源蛋白, 共享48% 的氨基酸序列[7], 在结构和功能上密切相关, 并且响应多种刺激参与炎症反应的激活及调控[5,8]。
在这里，我们报告了TAB2的鉴定，TAB2是IL-1途径中的一种新型中间体，其功能上将TAK1连接至TRAF6。 TAB2的表达诱导JNK和NF-κB激活，而显性负突变TAB2则通过IL-1削弱其激活。
