tetr家族

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baike.baidu.com

tetR - 百度百科

TetR是广泛分布于细菌中的转录调节蛋白家族,包含2000多个成员,其中仅约100个具有完整的特征结构,具有螺旋-转角-螺旋DNA结合域,通过形成同型二聚体结合靶DNA序列行使转录抑制功能,主要调控药物外排、抗生素合成等生理过程。其典型代表为大肠杆菌Tn10编码的TetR蛋白,可通过结合四环素解除对 ...

pmc.ncbi.nlm.nih.gov

The TetR Family of Regulators - PMC

The TetR family of regulators (TFRs) is a large and important family of one-component signal transduction systems (13, 14). While members of this family are best known for their roles as regulators of antibiotic efflu...

cjb.ijournals.cn

TetR家族转录调控因子配体的研究进展

摘要:TetR家族转录调控因子 (TetR family transcriptional regulators,TFRs) 广泛分布于细菌与古菌中,最早被发现的是可控制大肠杆菌四环素外排泵的TetR。 TFRs拥有DNA结合和多样的配体感知能力,其作用机制复杂。

onlinelibrary.wiley.com

TetR and OmpR family regulators in natural product ...

Here, we focus on the TetR and OmpR family TRs, which belong to OCS and TCS, respectively. These TR families are well-known examples of regulators in secondary metabolism and are ubiquitous across different bacteria, ...

pubmed.ncbi.nlm.nih.gov

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Bacteria transcriptional regulators are classified by their functional and sequence similarities. Member of the TetR/AcrR family is two-domain proteins including an N-terminal HTH DNA-binding motif and a C-terminal li...