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THP1-Dual™ cells feature the Lucia gene, a secreted luciferase reporter gene, under the control of an ISG54 minimal promoter in conjunction with five IFN-stimulated response elements.
THP1-Dual™ hTLR3 cells are engineered human monocytic reporter cells designed for studying TLR3-dependent pathways. They overexpress the human TLR3 gene, allowing for analysis of NF-κB and IRF responses to double-stra...
To download a certificate of analysis for THP-1 (TIB-202), enter the lot number exactly as it appears on your product label or packing slip. The certificate of analysis for that lot of THP-1 (TIB-202) is not currently...
Apr 10, 2025 · Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB bind...
We have implemented an improved, cost-effective, and highly reproducible protocol for a simple and rapid differentiation of the human leukemia monocytic cell line THP-1 into surrogates for immature dendritic cells (iD...
THP-1 is a human leukemia monocytic cell line, which has been extensively used to study monocyte/macrophage functions, mechanisms, signaling pathways, and nutrient and drug transport. This cell line has become a commo...
They feature two inducible reporter genes, allowing the concomitant study of the IRF and NF-κB pathways, by monitoring the Lucia luciferase and SEAP (secreted embryonic alkaline phosphatase) activities, respectively.
Download scientific diagram | (a) Type I interferon (IFN) pathway activation in THP1-Dual™ cells after cGAMP and LPS challenges (n = 4 independent experiments).
THP1-Dual cells were derived from the human THP-1 monocyte cell line by stable integration of two inducible reporter constructs.
THP1-Dual™ MD2-CD14-TLR4 and their control derive from the human leukemia monocytic THP-1 cells. This cell line has become a common model to study monocyte/macrophage functions, mechanisms and signaling pathways.
