Searching…
Jul 17, 2025 · Diseases associated with WDR26 include Skraban-Deardorff Syndrome and Autism Spectrum Disorder. Among its related pathways are Regulation of pyruvate metabolism and Respiratory electron transport.
WDR26 ... WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene. [5]
Mutations in WDR26 lead to Skraban-Deardorff, an intellectual disability syndrome with clinical features resembling other disorders arising from defects in transcriptional regulation and chromatin structure.
Jan 16, 2020 · Key Points Wdr26 is a critical regulator of nuclear condensation during red blood cell development in mammals and fish. Wdr26 functions as a core subunit of an E3 ubiquitin ligase complex to promote the...
Jun 7, 2013 · We have recently shown that Gβγ-mediated signal transduction in leukocytes depends on a novel Gβγ-interacting protein, WDR26 (16). WDR26 has been implicated in the regulation of the MAPK signaling pathwa...
据报道,WDR 蛋白家族中的Gβ、RACK1、RbAp46/48 (retino blastoma-binding protein46/48)、FBW7、WDR26 (WD repeat containing protein 26)以及信号途径调控因子hPIP2均可调控信号转导,并在肿瘤发生过程中发挥作用。
May 16, 2024 · Here, we discover that human WDR26 binds the metabolic enzyme nicotinamide/nicotinic-acid-mononucleotide-adenylyltransferase 1 (NMNAT1) and mediates its CTLH E3-dependent ubiquitylation independently of...
该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域，通常由 gly-his 和 trp-asp (GH-WD) 括起来，这可能有助于异源三聚体或多蛋白复合物的形成。 该家族的成员参与多种细胞过程，包括细胞周期进程、信号转导、细胞凋亡和基因调控。
在这里，我们报告鉴定和鉴定新型人类WD40重复蛋白WD40重复蛋白26（WDR26）。 WDR26的cDNA是3，729 bp，在细胞质中编码514个氨基酸的Gbeta样蛋白。
Aug 15, 2017 · WDR26 is evolutionarily conserved from yeast to human. Northern blot analysis detected a 3.7-kb WDR26 transcript in most adult human tissues, with highest expression in skeletal muscle and heart.
