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Targeting HER2 genomic alterations in non-small cell lung ...
May 4, 2021 · ERBB2 (HER2) A775_G776insYVMA is also named Y772_A775dup, E770_A771insAYVM, or A771_M774dup, in the scientific literature depending on the hypothetical explanation for the molecular mechanism of the YVMA...
www.oncokb.org
Somatic ERBB2 Y772_A775dup in Non-Small Cell Lung Cancer ...
ERBB2, a receptor tyrosine kinase, is altered by mutation, amplification and/or overexpression in various cancer types, most frequently in breast, esophagogastric and endometrial cancers. The ERBB2 Y772_A775dup altera...
www.nature.com
Molecular landscape of alterations in 3000 advanced NSCLC ...
In both cohorts, among oncogenic alterations of ERBB2, exon 20 insertion Y772_A775dupYVMA was the most frequent alteration (58% vs 41.6% in the Chinese vs the US), followed by...
ascopubs.org
Spectrum of HER2 alterations in NSCLC: Comparative analysis ...
The most frequent HER2 exon 20 variant was p.Y772_A775dup variant (76.5% in tissue, 71.4% in liquid biopsy), followed by p.E770_A771insAYVM (17.6% in tissue and 7.1% in liquid).
pmc.ncbi.nlm.nih.gov
Targeting HER2 genomic alterations in non-small cell lung ...
ERBB2 (HER2) A775_G776insYVMA is also named Y772_A775dup, E770_A771insAYVM, or A771_M774dup, in the scientific literature depending on the hypothetical explanation for the molecular mechanism of the YVMA insertion (il...
www.ncbi.nlm.nih.gov
ERBB2 NP_004439.2:p.Y772_A775dup (Concept Id: C3274006 ...
A tandem duplication of four amino acids, tyrosine-valine-methionine-alanine, between the alanine at position 775 and the glycine at position 776 of the receptor tyrosine-protein kinase erbB-2 protein.
www.jto.org
Conformational Landscapes of HER2 Exon 20 Insertions Explain ...
Dec 15, 2019 · In this study, to provide structural insights into the mechanism of activation and response heterogeneity of ex20ins, we carried out structural and molecular dynamics (MD) analysis of two common HER2 in...