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Jan 14, 2026 · GeneCards Summary for CDC45GeneCDC45 (Cell Division Cycle 45) is a Protein Coding gene. Diseases associated with CDC45 include Meier-Gorlin Syndrome 7 and Meier-Gorlin Syndrome 1. Among its related path...
Dec 26, 2024 · CDC45基因概述 CDC45，全名细胞分裂周期45（cell division cycle 45），位于染色体22q11.21上，是一个编码蛋白质的基因。 它的主要功能与细胞分裂密切相关，特别是在DNA复制和染色体分离过程中扮演重要角色。
Recently, pathogenic variants in the CDC45 (Cell Division Cycle protein 45) gene, located within the LCR22A–LCR22B region of chromosome 22q11.2, were noted to be involved in the pathogenesis of craniosynostosis.
CDC45（Cell Division Cycle 45）是DNA复制起始和细胞周期调控的关键基因，属于CDC45/MCM2-7/GINS（CMG）解旋酶复合体的核心成员。 该基因在真核生物中高度保守，主要功能是启动DNA复制，确保基因组在细胞分裂时准确复制。
Mar 1, 2024 · Cell cycle factor Cdc45, a member of this superfamily, is crucial for movement of the replication fork during DNA replication and an important component of the replisome.
Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA Polymerase, which is important for early steps of DNA replication in eukaryot...
Jan 5, 2025 · The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication.
